Nitric Oxide (NO) and p53

Cancer Cancer Cell Lines
1

What is the relationship between Nitric Oxide (NO) and p53. in regards to inflammatory response and tumorigenesis?

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Daniel

Nitric Oxide’s (NO) relationship with p53 is dual and depends on its concentration and duration of exposure, especially during chronic inflammation. At low levels, NO can activate wild-type p53 to cause growth arrest or apoptosis, which are anti-cancer effects.

However, high levels of NO from chronic inflammation can act as a mutagen, damaging DNA and causing mutations that inactivate p53 or leading to the accumulation of mutant p53 protein, which promotes tumor progression and metastasis.

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