Inhibitors of telomerase

Genetics Gene Delivery
1

Hello

I need some inhibitors of telomerase alternative splicing.

Thanks

2

Navneet

You can check the following compounds

  • Pladienolide B and its derivatives target the SF3B1 subunit of the U2 snRNP splicing complex, affecting the splicing of various genes, including hTERT.
  • Sudemycin is another SF3B1 inhibitor can disrupt the normal splicing of hTERT, leading to a reduction in active telomerase enzyme.
  • Resveratrol has been reported to influence alternative splicing of various genes and could potentially affect hTERT splicing indirectly by modulating splicing factors or regulatory pathways.
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