Recently, two groups of university students fellow me for scientific training, one for pharmacokinetics, the other for pharmacodynamics. Please help me design the different scheme to train them, respectively. Many thanks.
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yycui
Welcome to Scientist Solutions Discussion Boards. What lines are you planning to train them upon? What will be the duration of training? If you can provide a more elaborated response, it will help the users get a better organized response for you.
- For Pharmacodynamics - you can consider experiments and sessions focusing on the Ligand-Receptor Interactions, dose response analytics and biological effects.
- For Pharmacokinetics - consider experiments and sessions focusing on the drug absorption, distribution, bioavailability and Excretion.
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@yycui I suggest about creating a module based on following lines
| Aspect | Pharmacokinetics (PK) | Pharmacodynamics (PD) |
|---|---|---|
| Focus | Drug movement in the body (ADME) | Drug effects and mechanism of action |
| Software Training | Phoenix WinNonlin, R, MATLAB | SimBiology, NONMEM, GraphPad Prism |
| Practical Sessions | PK data analysis, modeling, and dosing regimen design | Dose-response analysis, receptor binding studies |
| Evaluation | Model-based projects, clinical simulations | Simulation projects, case studies |
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Dear Dr. Argerine, Many thanks for your concise response to my questions. Would you like to share your knowledges on how to search for and identify the possibible receptors on the outsite surface of cell membrane or in the cytoplasm or in nucleus? Please take a natural product as an example. Looking forward to your special response. Best
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Dear Dr. Navneet, many thanks for your lines concisely listed in the table for comparison. Would you like to further explain the evaluation in detail taking a natural product as an example? Looking forward to your kindly response. Best
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What exact type of receptor or compound are you looking for?
Dear Dr. gaganjot Singh, The receptors that can first bind with proanthocyanidins/anthocyanidins or proanthocyanidins /anthocyanins, then transmit the signalling into cytoplasm or cell nucleus, further lead to the expression of effective genes, and finally result in cellular response. Please share your experience to screen target receptors. Many thanks.
yycui
As far as i know there is no single “proanthocyanidin receptor”, but several receptor systems—SR-B1, GPCRs, ERs, AhR—are involved in the binding and signaling of anthocyanins, anthocyanidins, and proanthocyanidins, leading to **Cellular level gene expression changes - Long term signaling ** and cellular responses (immediate responses).
Dear Dr. Singh, Firstly, Many thanks for your providing the information of the several receptor systems-SR-B1, GPCRs, ERs,AhR. Secondly, would you like to share your experiences in screening the candidate receptors (Methods) and how to validate their ID as receptors, respectively? Looking forward to hearing from you. Best
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I have experience in isolation of receptor-ligand complexes for steroid receptors. Im primarily a Protein Chemist with specialization in Cancer Proteomics, Diagnostics and Immunology.
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Dear Dr. Singh, would you like to share your experience in isolation of receptor-ligand complexes for steroid receptors, e.g. protocols and/or the related published papers?