# Difference between tris cl & tris HCL?

**URL:** https://scientistsolutions.discourse.group/t/difference-between-tris-cl-tris-hcl/688
**Category:** Biochemistry
**Created:** [January 14, 2025, 12:53pm UTC](https://scientistsolutions.discourse.group/t/difference-between-tris-cl-tris-hcl/688 "2025-01-14T12:53:44Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![BarryArmstrong](https://avatars.discourse-cdn.com/v4/letter/b/8e7dd6/32.png) [@BarryArmstrong](https://scientistsolutions.discourse.group/u/BarryArmstrong)
#### Post date: [January 14, 2025, 12:53pm UTC](https://scientistsolutions.discourse.group/t/difference-between-tris-cl-tris-hcl/688/1 "2025-01-14T12:53:44Z")

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Hello

Does somebody help me out about the about tris-cl & tris-HCL difference?

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### Author: ![ARGERINE](https://avatars.discourse-cdn.com/v4/letter/a/8491ac/32.png) [@ARGERINE](https://scientistsolutions.discourse.group/u/ARGERINE)
#### Post date: [January 14, 2025, 8:46pm UTC](https://scientistsolutions.discourse.group/t/difference-between-tris-cl-tris-hcl/688/2 "2025-01-14T20:46:08Z")

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Hey Armstrong That’s a typical newbie dilemma … But we are here to resolve

- **Tris-Cl (Tris Hydrochloride):** Tris-Cl refers to a solution of Tris (tris(hydroxymethyl)aminomethane) base that has been titrated with HCl to a specific pH. It is used to maintain a stable pH in the solution where as,
- **Tris-HCl (Tris Hydrochloride):** Tris-HCl is a specific form of Tris that is already in the protonated form with HCl, making it a salt. It is commonly used to prepare buffers with a specific pH.