# CRISPRi vs. RNAi — Criteria for choosing the Right Approach

**URL:** https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131
**Category:** Gene Silencing
**Created:** [September 1, 2025, 8:34am UTC](https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131 "2025-09-01T08:34:21Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![BarryArmstrong](https://avatars.discourse-cdn.com/v4/letter/b/8e7dd6/32.png) [@BarryArmstrong](https://scientistsolutions.discourse.group/u/BarryArmstrong)
#### Post date: [September 1, 2025, 8:34am UTC](https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131/1 "2025-09-01T08:34:21Z")

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Hi All

For functional genomics, I’m debating between RNAi and CRISPRi for silencing. How do you decide which platform to use in your experiments?"

Can somebody answer this query…

Thanks

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### Author: ![HarmanAulakh](https://avatars.discourse-cdn.com/v4/letter/h/a87d85/32.png) [@HarmanAulakh](https://scientistsolutions.discourse.group/u/HarmanAulakh)
#### Post date: [September 1, 2025, 8:39am UTC](https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131/2 "2025-09-01T08:39:54Z")

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Hi Barry

RNAi works well for quick, temporary knockdowns but can be messy. CRISPRi is better if you want clear and lasting gene silencing.

Thnks