# Gene Silencing

**URL:** https://scientistsolutions.discourse.group/c/gene-silencing/447.md

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## [About the Gene Silencing category](https://scientistsolutions.discourse.group/t/about-the-gene-silencing-category/471)

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**Author:** [@harmandeep1618](https://scientistsolutions.discourse.group/u/harmandeep1618)\
**Replies:** 0\
**Last updated:** [August 26, 2024, 7:49pm UTC](https://scientistsolutions.discourse.group/t/about-the-gene-silencing-category/471 "2024-08-26T19:49:00Z")

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Discuss Biological Silencing, miRNA, piRNA (piwi-interacting RNA), RNAi / siRNA, Jobs and Meeting Announcements here:

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## [CRISPRi vs. RNAi — Criteria for choosing the Right Approach](https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131)

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**Author:** [@BarryArmstrong](https://scientistsolutions.discourse.group/u/BarryArmstrong)\
**Replies:** 1\
**Last updated:** [September 1, 2025, 8:39am UTC](https://scientistsolutions.discourse.group/t/crispri-vs-rnai-criteria-for-choosing-the-right-approach/1131 "2025-09-01T08:39:54Z")

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Hi All For functional genomics, I’m debating between RNAi and CRISPRi for silencing. How do you decide which platform to use in your experiments?" Can somebody answer this query… Thanks

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## [Intron between your sense and antisense gene for hairpin loops](https://scientistsolutions.discourse.group/t/intron-between-your-sense-and-antisense-gene-for-hairpin-loops/773)

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**Author:** [@Navneet](https://scientistsolutions.discourse.group/u/Navneet)\
**Replies:** 0\
**Last updated:** [January 16, 2025, 9:43am UTC](https://scientistsolutions.discourse.group/t/intron-between-your-sense-and-antisense-gene-for-hairpin-loops/773 "2025-01-16T09:43:41Z")

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Hi, just wondering if there is any papers or research that has shown the optimum size of the intron between your sense and antisense gene for hairpin loops. if not is there any obvious reasons as to why one couldn’t liga…

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## [SiRNA delivery for treatment of knok-in disease](https://scientistsolutions.discourse.group/t/sirna-delivery-for-treatment-of-knok-in-disease/769)

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**Author:** [@sachinsharma95](https://scientistsolutions.discourse.group/u/sachinsharma95)\
**Replies:** 0\
**Last updated:** [January 16, 2025, 9:33am UTC](https://scientistsolutions.discourse.group/t/sirna-delivery-for-treatment-of-knok-in-disease/769 "2025-01-16T09:33:05Z")

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I would like to know about how a SiRNA delivery can be used in the treatment of a genetic disorder (deletion mutation) that can be produced by knock-in technology. Thanks in advance.